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Macrophages weaken TLR9 agonist antitumor activity through interacting with the anti-PD-1 antibody Fc domain

Macrophages weaken TLR9 agonist antitumor activity through interacting with the anti-PD-1 antibody Fc domain

by Dolly the Sheep | Mar 23, 2022 | Cancer, Immunology, in vivo Studies

A combination of TLR9 agonists and an anti-PD-1 antibody has been reported effective in immunocompetent mice. However, the role of innate immunity has not yet been explained. In a recent article published by the Cancers, by using Bio X Cell’s anti-mouse PD-1 in vivo...
Webinar: Discovering novel immunological clues in small fiber neuropathy with innovative techniques

Webinar: Discovering novel immunological clues in small fiber neuropathy with innovative techniques

by Dolly the Sheep | Mar 10, 2022 | Immunology, Neurology

WEBINAR: Discovering novel immunological clues in small fiber neuropathy with innovative techniquesative-techniques In this webinar, Dr. Chan will review the current literature on autoimmunity in SFN, and her journey into discovering novel autoantibodies in idiopathic...
Quick review on colon organoids and colon epithelial organoid culture recipe

Quick review on colon organoids and colon epithelial organoid culture recipe

by Dolly the Sheep | Mar 9, 2022 | Cancer, Organoids, Stem Cell

The Colon Organoids Using organoids as a model to study colorectal cancer Organoid limitations  Organoids to study the intestinal microbiome and host-pathogen interactions Perspectives Selected compositions for colon epithelial organoid culture recipe by...
Scientists identified TRAPPC4 as a crucial PD-L1 regulator

Scientists identified TRAPPC4 as a crucial PD-L1 regulator

by Dolly the Sheep | Feb 18, 2022 | Cancer, in vivo Studies

Tumour cells escape T cell-mediated immunosurveillance through the interaction between programmed death (PD-1) ligand 1 (PD-L1) on tumour cells and PD-1 on T cells. Strategies disturbing PD-1/PD-L1 have shown clinical advantages in various cancers. However, the...
Some recent developments on gastric organoid research and gastric epithelial organoid culture recipe

Some recent developments on gastric organoid research and gastric epithelial organoid culture recipe

by Dolly the Sheep | Jan 7, 2022 | Cancer, CRISPR, Organoids, Stem Cell

The Gastric Organoids Challenges in research on human stomach and gastric cancer Opportunities on organoid technology in scientific research Application of gastric organoids in research Example on limitation of current organoid research Some future trends on...
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