Cancer Articles

Single-cell DNA Analysis in Cancer Research and the Potential of Dynamic Therapy

Dr. Catherine Smith is a physician-scientist and an Assistant Professor in the Department of Medicine at UCSF. Her lab in the Division of Hematology/Oncology is focused on a subtype of AML (acute myeloid leukemia) characterized by mutations in FLT3, a gene that is...

Penetrating Cancer Stem Cells For Lung Cancer Treatment

Lung cancer is the leading cause of cancer-related mortality worldwide. Despite the recent advances in cancer research, about 70% of the patients with lung cancer present with locally advanced or metastatic disease at the time of the diagnosis. Although chemotherapy...

Anti-tumor T cell responses through LAG-3 blockade

Lymphocyte-activation gene 3 (LAG-3) is a receptor that negatively regulates the proliferation, activation, and effector function of T cells. Currently, monoclonal antibodies that block the interaction of LAG-3 with its canonical ligand, MHC-II, are being evaluated...

Targeting sphingolipid metabolism enhances cancer immunotherapy

CTLA-4 and PD-1 based immunotherapies have demonstrated significant clinical efficacy in melanoma patients, but many patients remain non-responsive and relapse is common. To try and improve the response rate, researchers are currently working to develop innovative...

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