Cancer Articles

Role of Ln-γ2 and TGF-β1 in anti-PD-1 therapy

OverviewThe PD-1/PD-L1 immune checkpoint plays an important role in serving immune escape for tumor cells. Tumor cells can bypass antitumor immunity by manipulating these immune checkpoints. In a research article from Frontier, the authors commented that immunotherapy...

How CRISPR editing is advancing cancer cell line research

Dr. Rebecca Roberts from Synthego has recently published an article discussing applications of CRISPR in cancer cell lines and how CRISPR editing is advancing cancer cell line research. The advent of CRISPR genome engineering technology has enabled many breakthroughs...

How PDL1-PD1 immune checkpoint inhibits T cell activation

OverviewScience Advance has recently published a research article discussing how the PDL1-PD1 immune checkpoint inhibits T cell activation. Checkpoint immunotherapy is known to be a revolutionizing treatment for previously refractive tumors. However, researchers had...

Single-cell DNA Analysis in Cancer Research and the Potential of Dynamic Therapy

Dr. Catherine Smith is a physician-scientist and an Assistant Professor in the Department of Medicine at UCSF. Her lab in the Division of Hematology/Oncology is focused on a subtype of AML (acute myeloid leukemia) characterized by mutations in FLT3, a gene that is...

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