<p>Overview Science Advances has published an article discussing the role of neutrophil and programmed death ligand 1 (PD-L1) pathways in wound healing of a burn injury. Below are some highlighted topics from the article: • Importance of proactive infection control in burn injury• Role of neutrophils in a burn injury• Programmed death ligand 1 (PD-L1) […]</p>

<p>Overview Cytotoxic T lymphocytes, also known as CD8+T cells, act a crucial role in regulating viral infection. They let out various toxic substances that can directly lead to the death of viral-infected cells. T cell receptors on cytotoxic T lymphocytes perceive signals given by MHC-Ι–peptide complex, eliminating cells that are responsible for viral replication and […]</p>

<p>Overview The PD-1/PD-L1 immune checkpoint plays an important role in serving immune escape for tumor cells. Tumor cells can bypass antitumor immunity by manipulating these immune checkpoints. In a research article from Frontier, the authors commented that immunotherapy targeting on PD1/PDL1 axis can effectively block its pro-tumor activity; however, only a subset of patients can […]</p>

<p>To support your in vivo studies, Bio X Cell is thrilled to announce a special back-to-school discount for all products! From now until 30 September 2021, you could enjoy an additional 15% off on top of your academic discount. Limited offer. Grab the chance to stock up your in vivo antibodies and jump-start your research! Get Quote Now Our top […]</p>

<p>Overview Interleukin-7 (IL-7) is a cytokine that has been known regarding its effects on T-cells and B-cells. Its signaling pathway has a crucial role in controlling T cell function and its survival. In the recent article published by Science Advances, the authors identified:   Overexpression of IL-7 in lesional skin from both humans and mice […]</p>

<p>Overview bioRxiv has recently released a preprint discussing a compelling neutralizing anti-SARS-CoV-2 antibody that hinders variants of concern. The authors identified one monoclonal antibody (mAB), the SARS2-38, powerfully neutralizes all SARS-CoV-2 variants of concern tested and protects mice against challenge by multiple SARS-CoV-2 strains. In the preprint, the structural analysis demonstrated that SARS2-38 employs a […]</p>

<p>Dr. Brittany Enzmann from Synthego has recently published an article discussing about why ribonucleoprotein (RNP) is a better alternative to CRISPR plasmids for CRISPR genome editing experiments. Below are highlights from the article: 1. RNPs Reduce the Total Experimental Time Plasmid-based CRISPR transfection requires multiple steps for the guide preparation and is more labor-intensive compared […]</p>

<p>Dr. Rebecca Roberts from Synthego has recently published an article discussing applications of CRISPR in cancer cell lines and how CRISPR editing is advancing cancer cell line research. The advent of CRISPR genome engineering technology has enabled many breakthroughs in the field of oncology. The author has looked into some of the key examples of CRISPR […]</p>

<p>Webinar: Multiple Somatic Mutations Synergize to Drive Cerebral Cavernous Malformations   In this webinar, Daniel Snellings from the Duke University Medical Centre shares the role of somatic mutations in the pathogenesis of vascular malformations with specific focus on Cerebral Cavernous Malformations, Hereditary Hemorrhagic Telangiectasia, and Sturge-Weber Syndrome. The goal of his work is to identify […]</p>

<p>Overview Science Advance has recently published a research article discussing how the PDL1-PD1 immune checkpoint inhibits T cell activation. Checkpoint immunotherapy is known to be a revolutionizing treatment for previously refractive tumors. However, researchers had found that only a portion of patients responded, and some responders gained resistance. In the article, researchers were inspecting how […]</p>