in vivo Studies Articles

LincRNA EPIC1 Mediates Immunotherapy Resistance

The ability of tumour cells to evade immune detection plays a critical role in tumour development. Although mechanisms of immune evasion have been characterized, understanding of how tumour cells avoid detection by the immune system and acquire resistance to...

Preventing Breast Cancer Metastasis: A Role for Cathepsin C Inhibitors

Breast cancer deaths are often the result of metastasis to distant organs including the lungs. Overcoming inhibitory mechanisms and establishing growth in new microenvironments is critical to the metastatic process. Using anti-mouse IL-1b (clone B122) and anti-mouse...

Role of neutrophil and PD-L1 pathway in wound healing of a burn injury

Burn injury has been correlated to acute respiratory distress syndrome (ARDS). ARDS makes patients with burn injury an increased risk of bacterial pneumonia. According to an article published by Clinical Infectious Diseases, approximately 40,000 burn injuries required...

Role of Ln-γ2 and TGF-β1 in anti-PD-1 therapy

OverviewThe PD-1/PD-L1 immune checkpoint plays an important role in serving immune escape for tumor cells. Tumor cells can bypass antitumor immunity by manipulating these immune checkpoints. In a research article from Frontier, the authors commented that immunotherapy...