ARTICLE FROM BIO X CELL

Why In Vivo Formulation Antibodies Are a Natural Fit

Technologies such as artificial intelligence, organ-on-a-chip systems, and in silico modeling are transforming early-stage drug discovery. Regulatory bodies including the FDA and NIH are increasingly supporting validated alternatives to animal testing where appropriate. As researchers accelerate the shift toward human-relevant, non-animal systems, ex vivo models are taking center stage in drug discovery and translational science. Scientists working with sensitive NAM (New Approach Methodology) assays such as organoids, organs-on-chip, 3D cell cultures, and traditional cell and tissue culture, require antibodies that meet exceptional standards of purity, consistency, and performance to ensure low cytotoxicity, low off target effects, and to minimize inconsistent experimental results.

In the recent article published by Bio X Cell, they highlighted how in vivo antibodies are able to help researchers bridge NAM studies with traditional in vivo work and discussed the advantages of using Bio X Cell functional antibodies for cross-platform compatibility.