Immune Checkpoint Antibodies – Antibodies For In Vivo Use

by | Sep 19, 2023 | Cancer, Immunology, in vivo Studies, Neurology

ARTICLE FROM BIO X CELL

Immune Checkpoint Antibodies

Bio X Cell has released an article discussing 29 key immune checkpoint proteins, including their background, as well as their roles in the immune system. The article also talked about their respective antibodies targeting the immune checkpoint proteins in mouse for use in research. This week, Dolly from LAB-A-PORTER has extracted some of the features from the article.

What Are Immune Checkpoints?

Immune checkpoints are regulators of the immune system which prevent the immune system from attacking self-antigens indiscriminately. While this is critical to preventing auto-immune disease it also causes the immune system to be ineffective in eradicating or suppressing cancer.

Tumor cells exploit certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. Because many of these immune checkpoints are initiated by ligand-receptor interactions, they can be readily blocked by antibodies.

Blocking these immune checkpoints allows antitumor activity to resume and is among the most promising approaches to activating therapeutic anti-tumor immunity.

Bio X Cell offers an extensive selection of antibodies targeting mouse immune checkpoint proteins for research use.

*All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use.

References:

  1. Bio X Cell, ‘Immune Checkpoint Antibodies’. Available at https://bioxcell.com/educational-articles/immune-checkpoint-antibodies/#Jump_check_immune-25-target

ABOUT BIO X CELL

Antibodies For In Vivo Research

Bio X Cell antibodies are formulated for in vivo experiments and used extensively in animal models of human disease. They feature greater than 95% purity, ultra-low endotoxin levels, and are presevative, stabilizer, and carrier protein-free. Bio X Cell has developed a wide range of antibodies for immuno-oncology, immunology, and neuroscience research. Their products are cited in over 15,000 publications that detail a broad range of applications, including in vivo cell-specific depletion, cytokine neutralization, immune checkpoint blockade, and more.

 

    • Exceptional Purity
    • Pathogen Free
    • Ultra-low Endotoxin Level
    • Advanced Binding Validation
    • Low Protein Aggregation
    • Marching Isotype Control Antibodies

Learn more on our comprehensive in-vivo research reagents today.

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