RESOURCES FROM KACTUS
Article: Virus-Like Particles (VLPs) – Role in Immune Response
Virus-like particles (VLPs) are nanoparticle structures (50-300nm diameter) that mimic the organization and conformation of authentic native viruses but lack the viral genome, making them non-infectious. VLPs have been used extensively for vaccine development. Recently, VLPs have been leveraged to display target antigens that would otherwise be difficult to express. This includes transmembrane proteins such as G protein-coupled receptors (GPCRs) or solute carrier proteins (SLCs), which have multiple transmembrane regions and are hard to express in a native conformation without a natural membrane structure. Additionally, VLPs can be used to boost the immunogenicity of target antigens that would otherwise be difficult to generate antibodies against.
KACTUS published an article in discussing the role of virus-like particles (VLPs) in immune response, including:
- Engaging Humoral and Cellular Immune Responses
- VLP Proteins in Antibody Discovery
KACTUS offers a selection of various full-length multi-transmembrane proteins displayed on VLPs for antibody discovery and screening. Explore more on the product catalog of multipass transmembrane proteins displayed on virus-like particles (VLPs) or copolymer nanodiscs by KACTUS.
*All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use.
OUR TOP PRODUCT PICKS
Biotinylated Human Cystine/glutamate transporter (SLC7A11) Protein-Nanodisc (XCT-HM10NB)
Biotinylated Human CXCR5 Protein-Nanodisc (CXC-HM1RNB)
Biotinylated Human GCGR/Glucagon receptor Protein-Nanodisc (GCR-HM10NB)
Biotinylated Human GIPR Protein-Nanodisc (GIP-HM14RNB)
Biotinylated Human CD9 Protein-Nanodisc (CD9-HM40NB)
Human PC2/Polycystin-2 Protein-Nanodisc (PC2-HM10N)
FITC-equivalent Biotinylated Human CCR4 Protein-Nanodisc (CR4-HM4N188BF)
Biotinylated Human CCR5 Protein-Nanodisc (CR5-HM4N191B)
FITC-equivalent Biotinylated GLP-1R Protein-Nanodisc (GLP-HM4N185BF)
FITC-equivalent Human Claudin 1 Protein-Nanodisc (CLD1-HM1N184)
Biotinylated Human TM4SF15 Protein-Nanodisc (TSF15-HM4N174B)
FITC-equivalent Human TM4SF15 Protein-Nanodisc (TSF15-HM1N166)
Human APLNR Protein-VLP (APL-HM0P112)
Human CX3CR1 Protein-VLP (CXR-HM00V)
Human GCGR/Glucagon receptor Protein-VLP (GCR-HM00V)
FITC-equivalent Human Claudin 3 Protein-VLP (CLD3-HM0P96)
Biotinylated Human CD20 Protein-VLP (CD2-HM123B)
Human Claudin 18.2 Protein-VLP (CLD-HM0P37)
Explore more on the full product offerings on Transmembrane Proteins – Displayed on VLP & Nanodiscs
*All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use.
ABOUT KACTUS
Provides quality recombinant proteins and enzymes that accelerate therapeutic development
Founded in 2018, KACTUS is a leading manufacturer of recombinant proteins and enzymes, providing both off-the-shelf products and custom protein services. Their extensive catalog includes over 3,000 recombinant proteins, featuring antibody drug targets, cytokines, transmembrane proteins, MHC monomers and tetramers, immune checkpoint proteins, biotinylated proteins, and more. They also offer AAV titration ELISA kits, GMP-grade gene editing enzymes, and other GMP enzymes. All their products undergo rigorous testing for purity and bioactivity to ensure quality performance and consistency. KACTUS is ISO 13485:2016 certified and operates state-of-the-art facilities, including a 10,000 sq. meter GMP-grade manufacturing site.