KACTUS
Founded in 2018, KACTUS is a leading manufacturer of recombinant proteins and enzymes, providing both off-the-shelf products and custom protein services. Their extensive catalog includes over 3,000 recombinant proteins, featuring antibody drug targets, cytokines, transmembrane proteins, MHC monomers and tetramers, immune checkpoint proteins, biotinylated proteins, and more. They also offer AAV titration ELISA kits, GMP-grade gene editing enzymes, and other GMP enzymes. All their products undergo rigorous testing for purity and bioactivity to ensure quality performance and consistency. KACTUS is ISO 13485:2016 certified and operates state-of-the-art facilities, including a 10,000 sq. meter GMP-grade manufacturing site.
ABOUT THE SUPPLIER
Advanced Protein Engineering & Expression
KACTUS’ products are developed using their proprietary protein engineering platform, SAMS™: Structure Aided Multiplex Screening. 3D protein structures are optimized using advanced bioinformatics, structural analysis, and 3D modeling. Multiple protein constructs are tested in various expression conditions to optimize activity, yield, and configuration. With this platform, they have produced a catalogue of multi-pass transmembrane proteins such as CCR8, Claudin 18.2, and MRGPRX2. Additionally, they’ve developed off-the-shelf MHC monomers and tetramers, cytokines, HLA-G proteins, CD3 proteins, cadherins, integrins, T-cell therapy targets, and other recombinant proteins. All their products undergo purity and bioactivity validation to ensure optimal performance.
FEATURED PRODUCTS
Full-length human claudin 18.2
Demonstrating the strength of their SAMS™ technology platform, KACTUS was one of the first companies to produce full-length Claudin 18.2, a popular drug discovery target featuring four transmembrane domains.
200+ MHC Monomers & Tetramers
KACTUS has developed a series of MHC complexes, including monomers, tetramers, chimeric MHCs, and peptide-ready MHCs, as well as related custom services. Their MHC complex portfolio covers popular targets such as NY-ESO-1, KRAS, AFP, and HPV16 which can be used to meet the diverse needs of immunology, molecular screening, TCR affinity validation, blocking assays, and other applications.
VLP & Nanodisc Displayed Antigens
KACTUS has successfully developed a series of full-length multi-pass transmembrane proteins displayed on VLPs. These targets include Claudin 18.2, GPRC5D, Claudin 6, CD20, and more. Their VLP-displayed proteins overcome the technical barriers of membrane protein expression and stability.
AAV Titration ELISA Kits
Research-grade & preclincal-grade Laminin 521
KACTUS has developed quality Laminin 521 products that can be applied to scientific research (research-grade) and preclinical development (preclinical-grade). It can effectively support the normal growth and passage of PSCs, maintain good stemness, and ensure the homogeneous growth of cells with genetic stability. Laminin 521 can be applied to the cultivation of stem cells and other primary cells and the development of related stem cell products.
Bioactive CD3 Homodimers, Heterodimers, & Monomers
Through their unique SAMS™ protein engineering and expression platform, KACTUS provides a variety of highly active CD3 proteins, including monomers, dimers, and other forms, to meet the diverse needs of researchers in immunology, antibody preparation, and screening.
Cell Culture Cytokines with verified cellular-level activity
They have developed a catalogue selection of high-quality cytokines covering various categories, including interleukins (IL), colony-stimulating factors (CSF), and growth factors (GF). These products can be applied in organoid culture, maintenance of cell growth in vitro for immune cell therapy, and stem cell proliferation and differentiation.
*All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use.