RESOURCES FROM KACTUS
Article: CDCP1: A New Therapeutic Target for Malignant Tumors
Natasha Slepak from KACTUS recently published a new article talking about CDCP1: A New Therapeutic Target for Malignant Tumors.
CDCP1 (CUB Domain-Containing Protein 1) is a transmembrane protein overexpressed in cancers such as triple-negative breast, lung, and pancreatic cancer. It plays a critical role in tumor survival, metastasis, and drug resistance.
In the tumor microenvironment, CDCP1 is cleaved into N-terminal (ATF) and C-terminal (CTF) fragments. Phosphorylated CTF activates oncogenic MAPK and PI3K/AKT signaling. Development strategies focus on:
- Full-length CDCP1: Inhibiting expression or blocking cleavage.
- Cleaved CDCP1: Targeting neoepitopes exposed after proteolysis.
KACTUS Solutions
To support antibody discovery, KACTUS provides high-quality CDCP1 antigens in multiple formats—including full-length, ATF&CTF complexes, and specific domains—ensuring the proper folding necessary for targeting distinct epitopes.
Featured products
(CDC-HM101) Human CDCP1, His tag
(CDC-HM401B) Biotinylated Human CDCP1, His-Avi tag
(CDC-HM201) Human CDCP1, hFc tag
(CDC-HM102) Human CDCP1 ATF&CTF (fused by polypeptide linker), His tag
(CDC-HM104) Human CDCP1 ATF&CTF (co-transfected complex), HA, His tag
(CDC-HM10D) Human CDCP1 ATF (30-368), C-His tag
(CDC-HM11D) Human CDCP1 ATF (30-368), N-His tag
(CDC-CM102) Cynomolgus CDCP1, His tag
(CDC-CM101) Rhesus macaque CDCP1, His tag
(CDC-CM401B) Biotinylated Rhesus macaque CDCP1, His-Avi tag
(CDC-MM101) Mouse CDCP1, His tag
*All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use.
ABOUT KACTUS
Provides quality recombinant proteins and enzymes that accelerate therapeutic development
Founded in 2018, KACTUS is a leading manufacturer of recombinant proteins and enzymes, providing both off-the-shelf products and custom protein services. Their extensive catalog includes over 3,000 recombinant proteins, featuring antibody drug targets, cytokines, transmembrane proteins, MHC monomers and tetramers, immune checkpoint proteins, biotinylated proteins, and more. They also offer AAV titration ELISA kits, GMP-grade gene editing enzymes, and other GMP enzymes. All their products undergo rigorous testing for purity and bioactivity to ensure quality performance and consistency. KACTUS is ISO 13485:2016 certified and operates state-of-the-art facilities, including a 10,000 sq. meter GMP-grade manufacturing site.