RESOURCES FROM KACTUS
Article: Addressing Challenging Antibody Discovery Targets with Virus-like Particle (VLP) Transmembrane Proteins
Transmembrane proteins play crucial roles in cell signaling transduction, immune response regulation, and ion/small molecule transportation. Their involvement in diseases like cancer, autoimmune disorders, and infectious diseases makes them the prime targets for therapeutic antibodies. However, these proteins remain among the most challenging targets for antibody drug development due to the insolubility of membrane protein and difficulty of presenting in native confirmations under normal assay conditions.
Fortunately, the Virus-like particles (VLPs), are now reshaping this landscape by providing a natural bilipid layer to display transmembrane proteins in a soluble format with native target protein conformation. Additionally, the viral capsid structure of VLPs enhances the immunogenicity of membrane proteins with low abundance, making it a robust tool for antibody discovery. Here, KACTUS explores applications of VLP-displayed antigens in antibody discovery and screening including immunization, yeast display screening, and phage display screening.
In this article, KACTUS discussed how VLPs are unlocking the next generation of antibody therapeutics for challenging transmembrane proteins.
In this article, KACTUS discussed how VLPs are unlocking the next generation of antibody therapeutics for challenging transmembrane proteins.
*All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use.
OUR TOP PRODUCT PICKS
Biotinylated Human Cystine/glutamate transporter (SLC7A11) Protein-Nanodisc (XCT-HM10NB)
Biotinylated Human CXCR5 Protein-Nanodisc (CXC-HM1RNB)
Biotinylated Human GCGR/Glucagon receptor Protein-Nanodisc (GCR-HM10NB)
Biotinylated Human GIPR Protein-Nanodisc (GIP-HM14RNB)
Biotinylated Human CD9 Protein-Nanodisc (CD9-HM40NB)
Human PC2/Polycystin-2 Protein-Nanodisc (PC2-HM10N)
FITC-equivalent Biotinylated Human CCR4 Protein-Nanodisc (CR4-HM4N188BF)
Biotinylated Human CCR5 Protein-Nanodisc (CR5-HM4N191B)
FITC-equivalent Biotinylated GLP-1R Protein-Nanodisc (GLP-HM4N185BF)
FITC-equivalent Human Claudin 1 Protein-Nanodisc (CLD1-HM1N184)
Biotinylated Human TM4SF15 Protein-Nanodisc (TSF15-HM4N174B)
FITC-equivalent Human TM4SF15 Protein-Nanodisc (TSF15-HM1N166)
Human APLNR Protein-VLP (APL-HM0P112)
Human CX3CR1 Protein-VLP (CXR-HM00V)
Human GCGR/Glucagon receptor Protein-VLP (GCR-HM00V)
FITC-equivalent Human Claudin 3 Protein-VLP (CLD3-HM0P96)
Biotinylated Human CD20 Protein-VLP (CD2-HM123B)
Human Claudin 18.2 Protein-VLP (CLD-HM0P37)
Explore more on the full product offerings on Transmembrane Proteins – Displayed on VLP & Nanodiscs
*All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use.
ABOUT KACTUS
Provides quality recombinant proteins and enzymes that accelerate therapeutic development
Founded in 2018, KACTUS is a leading manufacturer of recombinant proteins and enzymes, providing both off-the-shelf products and custom protein services. Their extensive catalog includes over 3,000 recombinant proteins, featuring antibody drug targets, cytokines, transmembrane proteins, MHC monomers and tetramers, immune checkpoint proteins, biotinylated proteins, and more. They also offer AAV titration ELISA kits, GMP-grade gene editing enzymes, and other GMP enzymes. All their products undergo rigorous testing for purity and bioactivity to ensure quality performance and consistency. KACTUS is ISO 13485:2016 certified and operates state-of-the-art facilities, including a 10,000 sq. meter GMP-grade manufacturing site.