Bio X Cell antibodies are formulated for in vivo experiments and used extensively in animal models of human disease. They feature greater than 95% purity, ultra-low endotoxin levels, and are presevative, stabilizer, and carrier protein-free. Bio X Cell has developed a wide range of antibodies for immuno-oncology, immunology, neuroscience research and more. Their products are cited in over 15,000 publications that detail a broad range of applications, including in vivo cell-specific depletion, cytokine neutralization, immune checkpoint blockade, and more.

in vivo Antibodies

Bio X Cell has a growing library of 400+ antibodies specifically formulated for in vivo use-validated for purity and quality, readily-available in milligram to gram quantities, and quickly delivered.

Whether you need blocking antibodies against a specific target; functional antibodies or biosimilars to study biological effects; or quality anti-mouse antibodies to increase reproducibility, sensitivity, and specificity, you’ll find monoclonal antibodies (MAbs) for in vivo use that you can rely on.

Isotype Controls

Bio X Cell offers a wide selection of isotype control antibodies. Choosing the correct isotype control antibody is an important part of most antibody-based experiments. Isotype controls must match the species and isotype of the primary antibody of interest but have no specificity for the target species.

Isotype controls serve as negative controls, making it easy for the researcher to differentiate between non-specific background effects or signal and specific effects of the antibody of interest. This type of control is especially important to include in in-vivo or in-vitro blocking/neutralization/depletion/activation experiments when the readout is a phenotypic change. Their isotype controls are ready for in vivo administration, as no preservatives or stabilizers are added, and endotoxin levels are ultra-low.

InVivoPure™ antibody dilution buffers 

Bio X Cell InVivoPure™ antibody dilution buffers are specifically formulated and tested to satisfy the stringent requirements for in vivo applications. They are extremely low in endotoxin, have been screened for murine pathogens, and tested in animal models for toxicity. The InVivoPure™ antibody dilution buffers identically match the composition and pH of the buffer their antibodies are formulated in.

Fusion proteins

Fusion proteins are typically constructed by combining the binding domain of a cell surface receptor with the Fc portion of an antibody. The receptor portion functions as a decoy binding site to bind and capture ligand molecules that would otherwise bind to the endogenous receptor.

In this way fusion proteins are useful tools to block receptor signaling. Bio X Cell fusion proteins are specifically formulated for in vivo use. They feature greater than 95% purity, ultra-low endotoxin levels, and are preservative, stabilizer, and carrier protein-free.

Conjugated antibodies

Conjugated antibodies from Bio X Cell provide exceptional reliability for a range of applications, including multi-color flow cytometry, Fluorescence-activated cell sorting (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), and Immunocytochemistry (ICC).

Designed to support your experimental workflow beyond in vivo applications, these antibodies are ideal for identifying immune cell lineages, analyzing immune checkpoint markers such as PD-1 and LAG-3, and exploring novel therapeutic pathways.

Conjugated antibodies from Bio X Cell may be paired with target-specific, conjugated isotype controls to fluorophores such as PE, APC, and FITC to ensure consistent, high-quality results with reduced variability.

in vivo Recombinant antibodies

Bio X Cell’s recombinantly manufactured antibodies overcome the limitations of traditionally manufactured antibodies, including genetic drift, gene loss, and gene mutations which can lead to slight changes in binding specificity and antibody affinity over time. This ensures extremely high lot-to-lot consistency and data reproducibility from experiment to experiment.

Their recombinant antibodies are provided as chimeric antibodies with mouse or human IgG constant regions instead of the typical rat or hamster constant regions. This means improved in vivo activity and reduced immunogenicity in mouse and humanized mouse models.

InVivoSIM™ Biosimilar Antibodies

Bio X Cell InVivoSIM™ Biosimilar Antibodies are research-grade biosimilar monoclonal antibodies. Each biosimilar antibody is produced using recombinant technology and incorporates the same variable region sequence as the original pharmaceutical drug.

Biosimilar antibodies make it possible to study the biological effects of a drug without needing to source expensive pharmaceutical-grade therapeutics. They can be used for many research applications including functional assays, flow cytometry, ELISA, Immunohistochemistry, pharmacokinetic assays, and others.

InVivoSIM™ biosimilar antibodies are offered with the same purity and in vivo formulations that Bio X Cell is known for. Their biosimilar antibodies are of exceptional quality and consistency. They are ultra-pure and free of preservatives, stabilizers, and carrier proteins, making them ideal for in vivo applications including drug efficacy studies in humanized mouse models.

ReadyTag™ Antibodies

Recombinant proteins are often produced in vitro with a small antigenic sequence to which an antibody can bind specifically. The most commonly used of these tag epitopes include polyhistidine tag, HA tag, c-myc tag, as well as proteins like GFP and GST.

Anti-tag antibodies are useful for applications including Western blotting, ELISA, flow cytometric analysis, immunofluorescence, immunohistochemistry, and immunoprecipitation when working with tagged proteins. Their ReadyTag™ anti-tag antibodies are specifically formulated for in vivo use. They feature greater than 95% purity, ultra-low endotoxin levels, and are preservative, stabilizer, and carrier protein-free.

All products listed on this site and sold through LAB-A-PORTER Limited are for research use only (RUO). Not for human use. Not for therapeutic or diagnostic use.