KEY PUBLICATIONS USING QKINE
Journal article: Studying of chronic pancreatitis – patient-derived organoid biobank using Qkine’s growth factors
Qkine reported a journal article of Osorio-Vasquez et al. on the development of a patient-derived organoid biobank for the study of chronic pancreatitis and other pancreatic diseases. This will allow the development and testing of targeted therapeutics.
Chronic pancreatitis is a common disease, affecting >200,000 in America and 1 million worldwide. It is hard to predict whether acute pancreatitis will become chronic and there are multiple causative agents including gallstones, alcohol, tobacco and genetics as well as unknown causes.
In this study they demonstrated a 70-85% efficiency in culture of patient derived organoids, an improvement on the 10-40% efficiency previously found from iPSC cultures. This rapid and efficient creation of patient derived organoids with close similarity to patient tissue samples at the DNA and protein level is a step forward in the availability of organoids for the study of disease mechanisms and treatment.
This group used Qkine noggin and R-spondin 1 (RSPO1) in the culture of human and mouse normal pancreatic organoids and organoids derived from human chronic pancreatitis.
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ABOUT QKINE
A UK Manufacturer Provides Cost-Effective Highly Bioactive Growth Factors For Stem Cell and Organoid Research
Qkine manufactures high-purity, animal-free growth factors, cytokines and other complex proteins for stem cell and organoid culture. An ISO 9001: 2015 certified company based in Cambridge, UK, Qkine combines proprietary production processes with protein engineering technology to tackle fundamental biological and scale-up challenges.
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- Highly bioactive
- Animal-free to eliminate the risks of contaminating growth factors, viruses, and prions
- Manufactured in UK
- Clear QC data provided on every lot from our ISO 9001:2015 accredited facility
- Excellent lot-to-lot consistency to help increase the reproducibility of experiments
- High purity
- Long-term stability
- Multiple pack sizes to suit your research