FEATURED ANTIBODIES

GeneTex | HIF1 alpha antibody (GTX127309)

HIF1 alpha antibody recognizes HIF1 alpha (HIF1a) protein, which is a subunit of the heterodimeric transcription factor hypoxia-inducible factor-1 (HIF-1). HIF-1 is a master regulator of homeostatic adaption to hypoxia (low oxygen supply) in various physiological and pathological conditions including normal development and cancer.

Genetex | PARP antibody [N2C1], Internal (GTX112864)

PARP antibody (more specifically, PARP1 antibody) detects poly(ADP-ribose) polymerase (PARP)-1, which is involved in various biological mechanisms such as DNA repair, genomic stability, and programmed cell death. Preclinical and clinical studies showed that PARP inhibition is an effective anti-tumor modality, and thus PARP inhibitors have become essential components of various chemotherapeutic regimens against many malignancies.

GeneTex | beta Amyloid (1-42) antibody – Conformation Specific (GTX134510)

GeneTex’s “beta-Amyloid (1-42) antibody – Conformation-Specific (GTX134510, Rabbit pAb) against Aβ 1-42 oligomers can specifically detect amyloid plaques in the AD brain by IHC-P analysis. The superior specificity and sensitivity of GTX134510 was confirmed by dot blot and side-by-side IHC-P comparison.

GeneTex | PD-L1 antibody (GTX104763)

PD-L1 antibody recognizes programmed death-ligand 1 (PD-L1) protein, also known as B7 homolog 1 (B7-H1) and cluster of differentiation 274 (CD274) protein. PD-L1 is found on various cancer cells and transduces immunosuppressive signals by binding to the programmed cell death protein 1 (PD-1) on effector T cells, thereby diminishing immune system attacks on malignant cells. Blocking the interaction between PD-L1 and PD-1 with PD-L1 antibodies is generating great clinical interest as a mode of immunotherapy against a number of cancers.