Retinal Organoid. This image (Credit: Anand Swaroop, Ph.D., NEI/NIH) is used under Public Domain Mark 1.0: https://creativecommons.org/publicdomain/mark/1.0/

Organoid models include three-dimensional (3D) cell culture systems that closely resemble in vivo organ or tissue. These 3D systems reproduce the complex spatial morphology of a differentiated tissue to allow biologically relevant cell-cell and cell-matrix interactions, ideally, sharing similar physiological responses with in vivo differentiated tissues.

The major focus of future organoid studies, beside the study of developmental processes, will most likely be in drug testing and disease modeling, such as developmental disorders, genetic conditions, cancer and degenerative disorders.

The hope is that organoids are another step in the long way towards in vitro construction of tissues and organs for transplantation in patients.

Selected compositions for organoid cultures by LAB-A-PORTER

KIDNEY ORGANOIDS
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Xia Y. et al. (2014) Nature Protocols. 9:2693.
Xia Y. et al. (2013) Nature Cell Biology. 15:1507.
Takasato M. et al. (2014) Nat. Cell Biol. 16:118

INNER EAR ORGANOIDS
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Koehler K.R. and E. Hashino (2014) Nat. Protocols. 9:1229.

RETINA ORGANOIDS
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Nakano T. et al. (2012) Cell stem cell. 10: 771

STOMACH ORGANOIDS
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Mahe M. et al. (2013) Curr. Protoc. Mouse Biol. 3:217
Sato T. and H. Clevers (2015) Cell. 161:1700
Bartfeld S. et al. (2015) Gastroenterology. 148:126

LIVER ORGANOID
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Mahe M. et al. (2013) Curr. Protoc. Mouse Biol. 3:217
Sato T. and H. Clevers (2015) Cell. 161:1700
Bartfeld S. et al. (2015) Gastroenterology. 148:126

PROSTATE ORGANOID
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Karthaus W.R. et al. (2014) Cell. 159:163.
Drost J. et al (2016) Nat. Protocols. 11:347

BRAIN ORGANOIDS
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Lancaster M.A. and J. A. Knoblich (2014) Nat. Protocols.
9:2329
Mariani J. et al. (2015) Cell. 162:375
Li Y. et al. (2017) Cell Stem Cell 20:1

IMMUNO GERMINAL CENTER-LIKE ORGANOIDS
Proteins & Growth Factors
3D Growth Matrix
References

Purwada A. and Singh A. (2017) Nat. Protocols. 12:168

MAMMARY ORGANOIDS
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Jardé T.et al. (2016) Nat. Commun. 7: 13207
Jamieson PR. et al. (2016) Develompent. :dev-145045

SMALL INTESTINAL AND COLONIC ORGANOIDS
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Mahe M. et al. (2013) Curr. Protoc. Mouse Biol. 3:217
Sato T. et al. (2011) Gastroenterology. 141:1762
Sato T. and H. Clevers (2015) Cell. 161:1700
Sato T. and H. Clevers (2009) Nature. 459:262
Jung P. et al. (2011) Nature Medicine. 17:1225

PANCREATIC ORGANOID
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Sato T. and H. Clevers (2015) Cell. 161:1700
Boj S.F. et al. (2015) Cell. 160:324.
Broutier L. et al. (2016) Nature Protocols. 11:1724

LUNG ORGANOID
Proteins & Growth Factors
Small Molecules
3D Growth Matrix
References

Dye B.R. et al. (2015) eLIFE. 4:e05098

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