Retinal Organoid. This image (Credit: Anand Swaroop, Ph.D., NEI/NIH) is used under Public Domain Mark 1.0: https://creativecommons.org/publicdomain/mark/1.0/
INTRODUCTION
Organoid
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from healthy individuals or patients that recapitulate the cellular heterogeneity, structure, and functions of human organs [1]. With the arrival of human 3D organoid systems, it is now possible to grant specific examination of stem cell morphogens, maintenance, and differentiation that are look-alike primary tissues, reinforcing the potential to research both human physiology and developmental stage[1]. At the same time, they are very much alike to their original organs and carry human genetic information, organoids derived from patients hold great promise for biomedical research and preclinical drug testing and are currently used for personalized, regenerative medicine, gene repair, and transplantation therapy[1]. In recent decades, researchers have successfully generated various types of organoids mimicking in vivo organs[1].
Emerging organoid technologies have brought opportunities for biomedical research[1]. The broader applications of organoids are in the beginning stage of exploration[1]. Extensive research will enable 3D organoid systems to replenish existing model systems, which could enhance basic and clinical studies in the future[1].
Reference:
[1] Tang, Xiao-Yan et al. “Human organoids in basic research and clinical applications.” Signal transduction and targeted therapy vol. 7,1 168. 24 May. 2022, doi:10.1038/s41392-022-01024-9
SELECTED ORGANOID REAGENTS AND TOOLS BY LAB-A-PORTER
Our Popular Organoid Reagents By Research Interests
Blood Vessel Organoid
Growth factors
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BMP-4
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FGF-basic
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VEGF-A
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Brain Organoid
Growth factors
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BDNF
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DKK-1
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EGF
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FGF-basic
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GDNF
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Noggin
Small molecules
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Dorsomorphin
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GDC-0068
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MK-2206
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Y-27632
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Endometrium Organoid
Growth factors
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EGF
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FGF-10
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HGF
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Noggin
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R-Spondin 1
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Esophagus Organoid
Growth factors
- Activin A
- BMP-4
- EGF
- FGF-basic
- FGF-10
- KGF
- Noggin
- Wnt-3a
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Fallopian Tube Organoid
Growth factors
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EGF
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FGF-10
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Noggin
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R-Spondin 1
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Wnt-3a
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Gallbladder Organoid
Growth factors
- EGF
- FGF-10
- HGF
- Noggin
- R-Spondin 1
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Heart Organoid
Growth factors
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FGF-basic
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TGF-beta 1
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Inner Ear Organoid
Growth factors
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BMP-4
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FGF-basic
Small molecules
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A 83-01
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LDN-193189
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SB 431542
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Intestinal Organoid
Growth factors
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Activin A
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EGF
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FGF-basic
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FGF-4
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IGF-1
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Noggin
-
R-Spondin 1
-
Wnt-3a
Small molecules
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A 83-01
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Nicotinamide
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SB 202190
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Y-27632
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Kidney Organoid
Growth factors
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Activin A
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BMP-2
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BMP-4
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BMP-7
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FGF-basic
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FGF-9
Small molecules
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CHIR 99021
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Retinoic Acid
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Y-27632
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Liver Organoid
Growth factors
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Activin A
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BMP-4
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BMP-7
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EGF
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FGF-basic,
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FGF-7
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FGF-10
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FGF-19
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HGF
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KGF
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Noggin
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OSM
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R-Spondin 1
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Wnt-3a
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TGF-alpha
Small molecules
- A 83-01
- DAPT
- Forskolin
- Gastrin
- Nicotinamide
- Prostaglandin E2
- Y-27632
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Lung Organoid
Growth factors
-
Activin A
-
FGF-basic
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FGF-4
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Noggin
-
FGF-10
Small molecules
- CHIR 99021
- SB 431542
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Mammary Organoid
Growth factors
- IGF-1
- Shh
- Wnt-3a
Small molecules
- CHIR 99021
- Y-27632
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Oral Mucosa Organoid
Growth factors
- EGF
- FGF-basic
- FGF-10
- Noggin
- R-Spondin 1
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Ovarian Surface Epithelium Organoid
Growth factors
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EGF
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NRG-1
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Noggin
-
R-Spondin 1
-
Wnt3a
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Pancreatic Organoid
Growth factors
-
Activin A
-
BMP-4
-
EGF
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FGF-4
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FGF-10
-
Noggin
-
R-Spondin 1
-
Wnt-3a
Small molecules
- A 83-01
- Gastrin,
- Nicotinamide
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Prostate Organoid
Growth factors
-
Activin A
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EGF
-
FGF-basic
-
FGF-10
-
Noggin
-
R-Spondin 1
Small molecules
-
A 83-01
-
SB 202190
-
Y-27632
-
Prostaglandin E2
-
Nicotinamide
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Retina Organoid
Growth factors
- IGF-1
- Shh
- Wnt-3a
Small molecules
- CHIR 99021
- Y-27632
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Skin Organoid
Growth factors
-
BMP-4
-
FGF-basic
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Stomach Organoid
Growth factors
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Activin A
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EGF
-
FGF-10
-
Noggin
-
R-Spondin 1
-
Wnt-3a
Small molecules
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A 8301
-
Gastrin
-
Nicotinamide
-
SB 202190
-
Y-27632
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
Urothelium Organoid
Growth factors
- FGF-basic
- FGF-7
- FGF-10
Xeno-free 3D hydrogel and medium
- Xeno-free 3D hydrogel for organoid
- Organoid Recovery Solution
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