Because the order of mutational acquisition and MRD detection make a difference.
Genome editing libraries are powerful tools to induce several mutations in human and mouse models of disease and enable the study of complex multi-mutational landscapes underlying cancer as well as numerous other diseases. Using single-cell DNA-seq, investigators can perform quality control on their genome-editing experiments and determine whether on- and off-target edits at multiple alleles have occurred in the same single cells.
Why Single Cell for Genome Editing Applications?
Genome editing requires tools for quality control to determine whether on- and off-target edits are being made in the same single cells. Single-cell DNA-seq data reveals all these combinations at multiple sites, directly from the DNA. These data can be acquired for both human cell line experiments or mouse model experiments. And, custom panels are easily designed using Tapestri Designer, which covers the entire human and mouse genome.
See how single-cell DNA sequencing applications provide a unique tool to interrogate at mouse models and genome editing experiments
Combine genome editing with mouse models to study solid tumors
Dr. John Lee , Fred Hutch
Measure multiple on- and off-target genome editing events
Custom Panels with Tapestri Designer
Kick off your single-cell research with a pre-designed panel in hematology or design your own using Tapestri Designer
Select panel content relevant to your specific indication to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several pre-designed targeted panels for hematologic cancers based on actionable clinical targets. Order the pre-designed panels as is, or easily add or subtract content to customize your research using Tapestri Designer.
DNA Is Our Foundation
Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.
Single-cell Genomics (DNA)
Single-cell Multi-omics (DNA+)
DNA + Protein
Clonal evolution impacts response, resistance, relapse, and residual disease
Profiling enables high resolution of the genomic diversity in a variety of tumor types
Model organisms and patient-derived xenografts for preclinical oncology research
Ready to learn more?
Use Tapestri Designer to design a custom panel tailored to your needs.