“Our mission is to help researchers and clinicians unlock single cell biology to enable the discovery, development, and delivery of precision medicine.”
Tapestri: The Precision Genomics Platform.
Clonal Resolution with Single Cell Precision
Complex disease evolves, so understanding genetic variability — including mutation co-occurrence at the single-cell level — is vitally important for clinical researchers to break the cycle of treatment response, resistance and relapse.
Evolving subclonal mutations can resist and escape treatment
“We have a profound gap in knowledge between the interaction of a person, their cancer, and their therapy and how that impacts response. We need better insight.”
Break Out of the Limitations of Bulk.
The average read-out from conventional bulk sequencing misses the underlying genetic diversity across cell populations. To improve patient stratification, therapy selection, and disease monitoring we need insights into mutation co-occurrence within every single cell by next generation sequencing (NGS).
The industry’s first scalable, customizable, single cell DNA sequencing platform.
The Mission Bio Tapestri Platform was developed to help advance precision medicine by enabling the accelerated and accessible detection of genomic variability within and across cell populations. Leveraging proprietary droplet microfluidics, the platform unlocks access to DNA by single cell sequencing with a novel two-step protease workflow. This methodology provides flexibility for additional applications and customization capability.
How the Tapestri Platform for Single Cell DNA Sequencing Works
High Sensitivity to Reveal True Heterogeneity
The Tapestri Platform revolutionizes the capability to directly assess the clonal architecture of a sample with detection of mutation co-occurrence patterns. Rather than inferring variants that co-occur within a subclone from comparable bulk variant allele frequencies, single cell resolution uncovers the true distribution of genotypes and their segregation patterns across subclones.
- Detect rare subclones down to 0.1%
- Resolve clonal architecture
- Identify mutation co-occurrence
- Targeted and accurate SNVs and indel variant calling
- Single cell DNA throughput up to 10,000 cells
- Simple workflow
- User-friendly bioinformatics software
- Customizable content