Technology Articles

Chapter 1: Small Molecules in Stem Cell & Cellular Reprogramming Research

In order to maintain the pluripotency of embryonic stem cells (ESCs), they are commonly cultured in the presence of feeder cells, serum and growth factors. Growth factors related to crucial signaling pathways involved in the maintenance of pluripotency have been...

Chapter 2: Improving Reprogramming Efficiency

Induced pluripotent stem cells (iPSCs) hold several advantages over embryonic stem cells (ESCs), including avoiding the ethical issues involved with ESCs, the availability of an “endless” cells source and the ability to generate genetically matching cells, which are...

Chapter 3: Chemically Induced Pluripotent Stem Cell

The use of human embryonic stem cells (hESCs) in research and for therapeutic applications is a controversial issue due to a combination of religious, political and ethical considerations. This led researchers to concentrate on adult stem cells as a source of...

Chapter 4: Chemical Transdifferentiation

Regenerative medicine, which can replace lost or damaged cells in a variety of tissues and organs, requires sufficient amounts of the desired competent cells for transplantation. Such cells can be obtained by the reprogramming of somatic cells into pluripotent stem...