Technology Articles

RNAi vs. CRISPR: Guide to Selecting the Best Gene Silencing Method

The process for drug discovery and therapeutic development heavily relies on correlating genotype to phenotype. The best way to achieve this is to disrupt gene function and analyze its phenotypic. Researchers can experimentally regulate gene expression and interrogate...

CRISPR: Knockouts For Loss-of-Function Experiments

History of CRISPR The foundational discoveries leading to the development of CRISPR-Cas9 technology date back to 1987, when researchers first identified palindromic segments of DNA in bacteria. At the time, the significance of these Clustered Regularly Interspaced...

RNAi: The Knockdown Pioneer

History of RNAi In 1990, researchers noticed for the first time that RNA could potentially suppress gene expression in plants. The underlying mechanism of this “erratic and reversible” gene suppression was not clear. It wasn’t until almost a decade later...

Small Molecules for COVID-19 Research

BioGems is proud to offer a targeted portfolio of small molecules for life science research. Small molecules are low molecule weight organic compounds that affect key biological pathways to allow for the control of cellular responses. Their small size allows them to...