BloG
Here finds you the updates from our reporter Dolly.
RNAi vs. CRISPR: Guide to Selecting the Best Gene Silencing Method
The process for drug discovery and therapeutic development heavily relies on correlating genotype to phenotype. The best way to achieve this is to disrupt gene function and analyze its phenotypic. Researchers can experimentally regulate gene expression and interrogate...
CRISPR: Knockouts For Loss-of-Function Experiments
History of CRISPR The foundational discoveries leading to the development of CRISPR-Cas9 technology date back to 1987, when researchers first identified palindromic segments of DNA in bacteria. At the time, the significance of these Clustered Regularly Interspaced...
RNAi: The Knockdown Pioneer
History of RNAi In 1990, researchers noticed for the first time that RNA could potentially suppress gene expression in plants. The underlying mechanism of this “erratic and reversible” gene suppression was not clear. It wasn’t until almost a decade later...
Small Molecules for COVID-19 Research
BioGems is proud to offer a targeted portfolio of small molecules for life science research. Small molecules are low molecule weight organic compounds that affect key biological pathways to allow for the control of cellular responses. Their small size allows them to...
CRISPR Tools to Accelerate COVID-19 Research and Development
The COVID-19 pandemic has led to an urgent response from the research and scientific community around the world. The scientific community needs innovative tools that enable rapid development of COVID-19 diagnostics, therapeutics, and vaccines. Synthego is supporting...
Anti-tumor T cell responses through LAG-3 blockade
Lymphocyte-activation gene 3 (LAG-3) is a receptor that negatively regulates the proliferation, activation, and effector function of T cells. Currently, monoclonal antibodies that block the interaction of LAG-3 with its canonical ligand, MHC-II, are being evaluated...
CRISPR Benchmark Report
CRISPR is easily one of the most popular tools in modern biology. Since its introduction in 2012, CRISPR-based publications have increased about 30 fold. With NIH funding for CRISPR-related projects per year crossing a billion dollars in 2020, it is safe to assume...
New Distributorship Announcement – The Well Bioscience
VITROGEL® HYDROGEL User-friendly and robust hydrogel for 3D cell culture research Effective 1 April 2020 LAB-A-PORTER Limited has been appointed as the official exclusive distributor of The Well Bioscience. LAB-A-PORTER Limited will distribute and provide technical...
Bioinformatic Design of Cas13 Guide RNAs Targeting SARS-CoV-2
The current worldwide Coronavirus pandemic poses a serious threat to our way of life, our economy, our health, and the health of our friends and families. During these challenging times, we have truly been inspired by the reaction of the scientific research community...
COVID-19 Assistance Program
CoV Assistance Program: Are you or someone you know currently researching the COVID-19 outbreak? Rockland is here to help. Register to receive complimentary CoV antibodies, 40% off related products, and/or 20% off related services. Let's work together to end this...
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[Bio X Cell] Free Microcentrifuge Tube Rack Giveaway
FREE MICROTUBE RACK Limited Offer. Be Quick.Bio X Cell and LAB-A-PORTER would like to say THANK YOU to our loyal Bio X Cell users! We are ready to giveaway FREE MICROTUBE RACK to our loyal researchers. Simply upload a photo of your old Bio X Cell antibody tube and...
Tips For Scientists to Effectively Work from Home
Social distancing and shelter-in-place orders currently in effect in response to the COVID-19 crisis have upturned work patterns of companies and academics alike. With several labs shutting down and grinding experiments to an abrupt halt, scientists find themselves...
Organoids – Mini organs in a dish
Organoid models include three-dimensional (3D) cell culture systems that closely resemble the in vivo organ or tissue from which they are derived. These 3D systems replicate the complex spatial morphology of a differentiated tissue, and allow biologically relevant...
Stem Cells: Links to Human Cancer and Aging
The human body develops from a single diploid cell called a zygote and contains at adulthood an estimated 85 trillion cells, of which more than 150 billion turn over every day. All of these cells originate from a tiny population of so-called "embryonic" and "adult"...
Targeting sphingolipid metabolism enhances cancer immunotherapy
CTLA-4 and PD-1 based immunotherapies have demonstrated significant clinical efficacy in melanoma patients, but many patients remain non-responsive and relapse is common. To try and improve the response rate, researchers are currently working to develop innovative...
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