Interleukin-7 (IL-7) is a cytokine that has been known regarding its effects on T-cells and B-cells. Its signaling pathway has a crucial role in controlling T cell function and its survival. In the recent article published by Science Advances, the authors identified:
Overexpression of IL-7 in lesional skin from both humans and mice with spot baldness
Exogenous IL-7 expedited the commencement of spot baldness by amplifying the development of alopecic T cells
Blocking of IL-7 cut off the progression of spot baldness and reversed early spot baldness in mice
Blocking of IL-7 receptor subunit alpha (IL-7Ra) significantly reduced the total number of most T cell subsets, but relative sparing of regulatory T cells (Tregs)
Short-term IL-7Ra blockade, with the combination of low doses of Treg-tropic cytokines, can strengthen therapeutic effects in the treatment of spot baldness
Did you know?
Spot baldness is a T cell-mediated autoimmune disorder that often leads to unpredictable hair loss.
According to an article published by Medical News Today in 2017, this illness affects approximately 6.8 million people in the United States.
Bio X Cell products are for research use only (RUO) and are NOT FOR THERAPEUTIC USE.
PeproTech products are for research use only and are not for therapeutic or diagnostic use.
The full article from Science Advances is available here: https://www.science.org/doi/epdf/10.1126/sciadv.abd1866
1. Zhenpeng Dai, Eddy Hsi Chun Wang, Lynn Petukhova, Yuqian Chang, Eunice Yoojin Lee and Angela M. Christiano. Blockade of IL-7 signaling suppresses inflammatory responses and reverses alopecia areata in C3H/HeJ mice. Science Advances. 2021 Apr 2. doi: 10.1126/sciadv.abd1866
2. James McIntosh. Alopecia Areata: Causes, Symptoms, and Treatment. Medical News Today, MediLexicon International, 22 Dec. 2017, www.medicalnewstoday.com/articles/70956#home-remedies
Bio X Cell has been supplying the research community for over 20 years with in vivo grade antibodies for biomedical research. It is Bio X Cell’s commitment to providing the highest quality monoclonal antibodies at lowest prices for in vitro and in vivo pre-clinical animal studies. Bio X Cell understands the strict quality criteria required for such studies and the financial limitations faced by many researchers.
PeproTech creates the building blocks of your life science research by manufacturing high-quality products that advance scientific discovery and human health. Since 1988, we have grown into a global enterprise with state-of-the-art manufacturing facilities in the US, and offices around the world.
With over 2,000 products, PeproTech has developed and refined innovative protocols to ensure quality, reliability, and consistency.