Overview

Interleukin-7 (IL-7) is a cytokine that has been known regarding its effects on T-cells and B-cells. Its signaling pathway has a crucial role in controlling T cell function and its survival. In the recent article published by Science Advances, the authors identified:

 

  • Overexpression of IL-7 in lesional skin from both humans and mice with spot baldness

  • Exogenous IL-7 expedited the commencement of spot baldness by amplifying the development of alopecic T cells

  • Blocking of IL-7 cut off the progression of spot baldness and reversed early spot baldness in mice

  • Blocking of IL-7 receptor subunit alpha (IL-7Ra) significantly reduced the total number of most T cell subsets, but relative sparing of regulatory T cells (Tregs)

  • Short-term IL-7Ra blockade, with the combination of low doses of Treg-tropic cytokines, can strengthen therapeutic effects in the treatment of spot baldness

Did you know?

 

Spot baldness is a T cell-mediated autoimmune disorder that often leads to unpredictable hair loss.

According to an article published by Medical News Today in 2017, this illness affects approximately 6.8 million people in the United States.

The full article from Science Advances is available here:  https://www.science.org/doi/epdf/10.1126/sciadv.abd1866

Reference:

1. Zhenpeng Dai, Eddy Hsi Chun Wang, Lynn Petukhova, Yuqian Chang, Eunice Yoojin Lee and Angela M. Christiano. Blockade of IL-7 signaling suppresses inflammatory responses and reverses alopecia areata in C3H/HeJ mice. Science Advances. 2021 Apr 2. doi: 10.1126/sciadv.abd1866

2. James McIntosh. Alopecia Areata: Causes, Symptoms, and Treatment. Medical News Today, MediLexicon International, 22 Dec. 2017, www.medicalnewstoday.com/articles/70956#home-remedies

 

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