Liver organoids are functional 3D in vitro model consisting of native hepatic cell types. They are widely used as a platform to answer research questions ranging from hepatic development and regeneration, detoxification and metabolism studies, liver disease modelling, and adult stem cell biology. Liver organoids preserve the key physiological features of the liver and are composed of spherical monolayer epithelium. They are obtained through isolation and expansion of stem and progenitor cells from liver stem cell niches.

In a recent study, researchers from Switzerland have developed a new chemically defined stable and non-immunogenic matrix that supports the growth of human liver organoids. It is a potential breakthrough for current treatments against non-alcoholic fatty liver disease but also a crucial step in future transplantations.

Mechano-modulatory synthetic niches for liver organoid derivation

Sorrentino, G., Rezakhani, S., Yildiz, E. et al. Nat Commun 11, 3416 (2020). https://doi.org/10.1038/s41467-020-17161-0

VitroGel® ORGANOID  are xeno-free (animal origin-free) hydrogels that support the growth of patient-derived organoids or organoids developed from pluripotent stem cells (PSCs).

VitroGel ORGANOID hydrogels are ready-to-use at room temperature and have a neutral pH, transparent, permeable, and compatible with different imaging systems. The solution transforms into a hydrogel matrix by simply mixing with the cell culture medium. VitroGel ORGANOID hydrogels are good for both 3D cell culture and 2D hydrogel coating applications.

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