siRNA (27 mer) Guaranteed knockdown for gene silencing

Genomewide siRNA coverage against human, mouse and rat


Trilencer-27 siRNA kit contains Dicer-Substrate duplexes that provide two critical improvements over the use of traditional 21mer siRNA designs. 27mer siRNA takes advantage of the natural processing by Dicer producing 10-fold higher potency and specificity than shorter 21mer RNAi forms. 27mer siRNA duplexes also evade the radar of the mammalian interferon response when expressed in mammalian cells and initiates strong and specific gene silencing.

By its optimal design, 27mer siRNA has the advantages of improved efficacy and minimal interferon response. Learn more about Dicer-Substrate technology in this Nature Publication.

Features & Benefits:

  • Genomewide coverage against human, mouse and rat
  • 27mer Dicer-substrate duplex–higher potency & minimal interferon response
  • Guaranteed gene knockdown (≥70%)

All of the OriGene siRNA product comes as a kit. It contains 3 unique 27mer siRNA duplexes with the size of 2 nmol each, one negative control and one buffer. Each gene specific siRNA is labeled as the kit catalog number plus a/b/c. For example,

Kit Catalog      Kit Component
  • 3 gene specific siRNAs : SRxxxxxxA, SRxxxxxxB, SRxxxxxxC
  • SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex – 2 nmol
  • SR30005, RNAse free siRNA Duplex Resuspension Buffer – 2 ml